The Casa Colombo-Museum of Porto Santo intends to constitute itself as the headquarters structure of a broader referential set, a polynuclear museum, in the identification of the history of Porto Santo.
It affirms itself as a space of recognition of the strategic position of Porto Santo in the context of Portuguese expansion. It also proposes areas dedicated to the presence of Christopher Columbus in the Madeira archipelago and its importance in the preparation of the great voyages, until the discovery of America. Cristovão Colombo had married the daughter of the first Don Santo Captain, Bartolomeu Perestrelo.
A third exhibition area evokes the sinking of the Sloot ter Hooge galleon, belonging to the Dutch Indies Company (V.O.C.), on the northern coast of the island of Porto Santo, on the way to Battavia, now Jakarta, Indonesia. These three thematic areas recall the succession of three major powers in world trade: Portugal, Spain and the Netherlands.